Tresaderm Solution

Tresaderm® Solution (thiabendazole dexamethasone neomycin sulfate solution) Dermatologic Solution TRESADERM is indicated as an aid in the treatment of certain bacterial mycotic and inflammatory dermatoses and otitis externa in dogs and cats. Both acute and chronic forms of these skin disorders respond to treatment with TRESADERM. Item Specifications: Use For: Dogs and Cats Size: 15ml Manufacturer: Merial DESCRIPTION Dermatologic Solution TRESADERM® (thiabendazole dexamethasone neomycin sulfate solution) contains the following active ingredients per mL: 40 mg thiabendazole 1 mg dexamethasone 3.2 mg neomycin (from neomycin sulfate). Inactive ingredients: glycerin propylene glycol purified water hypophosphorous acid calcium hypophosphite; about 8.5% ethyl alcohol and about 0.5% benzyl alcohol. INDICATIONS Many forms of dermatosis are caused by bacteria (chiefly Staphylococcus aureus Proteus vulgaris and Pseudomonas aeruginosa). Moreover these organisms often act as opportunistic or concurrent pathogens that may complicate already established mycotic skin disorders or otoacariasis caused by Otodectes cynotis. The principal etiologic agents of dermatomycoses in dogs and cats are species of the genera Microsporum and Trichophyton. The efficacy of neomycin as an antibacterial agent with activity against both gram-negative and gram-positive pathogens is well documented. Detailed studies in various laboratories have verified the significant activity thiabendazole displays against the important dermatophytes. Dexamethasone a synthetic adrenocorticoid steroid inhibits the reaction of connective tissue to injury and suppresses the classic inflammatory manifestations of skin disease. The formulation for TRESADERM combines these several activities in a complementary form for control of the discomfort and direct treatment of dermatitis and otitis externa produced by the above-mentioned infectious agents. PRECAUTIONS On rare occasions dogs may be sensitive to neomycin. In these animals application of the drug will result in erythema of the treated area which may last 24 to 48 hours. Also evidence of transient discomfort has been noted in some dogs when the drug was applied to fissured or denuded areas. The expression of pain may last 2 to 5 minutes. Application of Dermatologic Solution TRESADERM should be limited to period not longer than one week. While systemic side effects are not likely with topically applied corticosteroids such a possibility should be considered if use of the solution is extensive and prolonged. If signs of salt and water retention or potassium excretion are noticed (increased thirst weakness lethargy oliguria gastrointestinal disturbances or tachycardia) treatment should be discontinued and appropriate measures taken to correct the electrolyte and fluid imbalance. Store in a refrigerator 36 - 46°F (2 - 8° C). WARNING For topical use in dogs and cats. Avoid contact with eyes. Keep this and all drugs out of the reach of children. NADA 042-6